Formation of RBC

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  1. In early embryonic life, RBC are produced in the yolk sac.

 2. During middle trimester of gestation, it is produced in the liver and spleen

 3. During later part of gestation and after birth , it is produced by Red Bone marrow.

Upto the age of 20 , red bone marrow of almost all bone produced rbc , but after 20 only red bone marrow of Vertebrae , sternum, ribs and ilium produced RBC.

The process of formation of RBC is called Erythropoiesis.

Hormones required for Erythropoiesis are

 I. Erythropoietin (EPO) -secreted by kidneys.

 II. Thyroxine and Testosterone

Stages of Erythropoiesis are shown in following chart:-

 • It takes 7 days to form mature, non-nucleated RBC.

 • Life span of rbc -120 days

 • Site of fate of RBC - liver and spleen.


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