Pulmonary tb | Classiffication of drugs used in tuberculosis  | first line drugs | second line drugs  | second line newer drugs  | isoniazide | rifampicin | Uses of rifampicin  |

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Pulmonary tb is the bacterial infection of the lungs caused by mycobacterium tuberculosis... It can cause various symptoms like chest pain,difficulty in breadthing and severe coughing...


Classiffication of drugs used in tuberculosis 


1.first line drugs

 -isoniazid(H)
 -rifampicin(R) 
-pyrazinimide(z) 
-ethambutol(E)
 -streptomycin(S)

 2.second line drugs 

-thiacetazone(tzn)
 -para amino salicylic acide(pASA) 
-ethionamide(etm)
 -kanamycin(kmc) 
-amikacin(am) 
-capriyomycin(cpr) 

3.second line newer drugs 

-ciprofloxacin 
-ofloxacin
 -azithromycin
 -clarithromycin
 -rivabutn


isoniazide

 -first line anti tubercular drugs 
-it is bacteriostatic for resting bacili and bactericidal for rapidlly diving organism -act on both extracelluar and intracellular tb bacilli 
-MOA (inhibit the synthesis of mycolic acid which is present in the mycobacterial cel wall) -atypical mycobacteria are not inhibited by inh.
-given orally 
-metabolized in the liver
 -dose 5mg/kg /day maxm uptoo 300 mg / days can b given
 -side effects( peripheral neuritis,hepatotoxicity,psychotic behaviour)


rifampicin 

-broad spectrum anti tubercular drug
 -effectiv for both gm+ve and gm -ve bacteria 
-both intracellular and extracellular organism are affacted MOA(inhibit DNA dependant RNA polymerase ,bactericidal effect) 
- dose 10 mg/kg/day maximum 600mg /day 
-given orally 1 or 2 hr before breakfast.. 
Side effects-hepatitis,red urine,nausea,vomiting,fever,headache) CI-alcholics,chronic liver diseases,vascitis,old age .

Uses of rifampicin 

- tb

-leprosy 

-meningitis
 -brucellosis







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